Mark A. Jacobson, MD; Stephen M. Hahn, MD; Julie L. Gerberding, MD; Lee Belle, PharmD; Merle A. Sande, MD
Recurrence of salmonella bacteremia after appropriate antibiotic therapy has been well described in patients who have the acquired immunodeficiency syndrome (AIDS) (1-3). After antimicrobial therapy, isolates of Salmonella species from blood generally have remained sensitive to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol (standard therapies for salmonella bacteremia [1, 2]). However, in some cases of AIDS-associated salmonella bacteremia, breakthrough bacteremia has occurred despite appropriate antibiotic therapy (expected serum drug concentrations exceeded minimum inhibitory concentration [MIC] of the drug for the isolate) (2, 4).
Ciprofloxacin is an orally bioavailable quinolone antibiotic with a high ratio of steady-state serum concentration to in-vitro MIC for Salmonella
Mark A. Jacobson, Stephen M. Hahn, Julie L. Gerberding, Lee Belle, Merle A. Sande. Ciprofloxacin for Salmonella Bacteremia in the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1989;110:1027–1029. doi: 10.7326/0003-4819-110-12-1027
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Published: Ann Intern Med. 1989;110(12):1027-1029.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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