Mark A. Jacobson, MD; Stephen M. Hahn, MD; Julie L. Gerberding, MD; Lee Belle, PharmD; Merle A. Sande, MD
Recurrence of salmonella bacteremia after appropriate antibiotic therapy has been well described in patients who have the acquired immunodeficiency syndrome (AIDS) (1-3). After antimicrobial therapy, isolates of Salmonella species from blood generally have remained sensitive to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol (standard therapies for salmonella bacteremia [1, 2]). However, in some cases of AIDS-associated salmonella bacteremia, breakthrough bacteremia has occurred despite appropriate antibiotic therapy (expected serum drug concentrations exceeded minimum inhibitory concentration [MIC] of the drug for the isolate) (2, 4).
Ciprofloxacin is an orally bioavailable quinolone antibiotic with a high ratio of steady-state serum concentration to in-vitro MIC for Salmonella
Jacobson MA, Hahn SM, Gerberding JL, Belle L, Sande MA. Ciprofloxacin for Salmonella Bacteremia in the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1989;110:1027–1029. doi: 10.7326/0003-4819-110-12-1027
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Published: Ann Intern Med. 1989;110(12):1027-1029.
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