Egbert F. Smit, MD; Dirk Th. Sleijfer, MD; Sijtze Meijer, MD; Nanno H. Mulder; Pieter E. Postmus, MD
To the Editor: Reed and Jacob (1) report on renal toxicity following high-dose carboplatin (800 mg/m2 body surface) in patients pretreated with cisplatin who have refractory ovarian cancer. A substantial decrease in creatinine clearance was seen in three patients. In nine other patients who received vigorous intravenous hydration no reductions in creatinine clearance occurred. Mulder and colleagues (2) reported a case history of a patient who developed renal failure after a cumulative dose of carboplatin of 750 mg/m2 in 3 days. This patient was also pretreated with a regimen containing cisplatin. However, carboplatin has also proved to be nephrotoxic
Smit EF, Sleijfer DT, Meijer S, Mulder NH, Postmus PE. Carboplatin and Renal Function. Ann Intern Med. ;110:1034. doi: 10.7326/0003-4819-110-12-1034_1
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Published: Ann Intern Med. 1989;110(12):1034.
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