Elio Roti, MD; Eliana Gardini, MD; Roberta Minelli, MD; Mario Salvi, MD; Giuseppe Robuschi, MD; Lewis E. Braverman, MD
Thionamide drugs are traditionally administered in divided doses, a treatment schedule recommended in many textbooks of endocrinology and thyroidology. The reason for administering antithyroid drugs in divided doses is that they have a relatively short half-life in serum (1). More recent studies, however, have shown that the antithyroid effect of the thionamides is related to their half-life in the thyroid gland rather than in the serum. It has been reported that methimazole (Tapazole, Eli Lilly and Co., Indianapolis, Indiana) administered to hyperthyroid patients has a half-life in serum of 6.8 hours (2), stays in the thyroid for 20 hours (3),
Roti E, Gardini E, Minelli R, Salvi M, Robuschi G, Braverman LE. Methimazole and Serum Thyroid Hormone Concentrations in Hyperthyroid Patients: Effects of Single and Multiple Daily Doses. Ann Intern Med. ;111:181–182. doi: 10.7326/0003-4819-111-2-181
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Published: Ann Intern Med. 1989;111(2):181-182.
Endocrine and Metabolism, Thyroid Disorders.
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