David J. Wyler, MD
Malaria has been a scourge probably since the dawn of mankind. The earliest recorded history resides in cuneiform tablets dating back to 2000 BC that describe malarial fevers in Mesopotamia (1). One can well imagine that the profound acute morbidity and high mortality of falciparum malaria was a stimulus for man's earliest empiric efforts to find curative herbs. Quinine-the active alkaloid of the cinchona bark used empirically in treating periodic fevers-is a legacy of the centuries of struggle to identify febrifuges and plants with antimalarial properties. Today, with the emergence and dissemination of multidrug-resistant strains of Plasmodium falciparum (2), quinine
Wyler DJ. Fluoroquinolones for Malaria: The Newest Kid on the Block?. Ann Intern Med. ;111:269–271. doi: 10.7326/0003-4819-111-4-269
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Published: Ann Intern Med. 1989;111(4):269-271.
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