Edward A. Sasse, PhD; Basil T. Doumas, PhD; Jacob Lemann Jr., MD
To the Editor: Increased rates of albumin excretion into the urine at rest or after exercise exceeding about 3(μg/min or 45 mg/day are an early manifestation of diabetic nephropathy and may be a more sensitive indicator of the onset of diabetic nephropathy than the measurement of urinary total protein (1, 2). We evaluated whether measurement of urinary albumin, a more difficult and costly procedure, offers any advantage over the measurement of urinary total protein in following patients with established diabetic nephropathy.
We studied 11 patients with established type I diabetic nephropathy. These patients were entered in the Collaborative Study of
Edward A. Sasse, Basil T. Doumas, Jacob Lemann. Diabetic Nephropathy: Urinary Albumin or Total Protein?. Ann Intern Med. 1989;111:343–344. doi: 10.7326/0003-4819-111-4-343_2
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Published: Ann Intern Med. 1989;111(4):343-344.
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