Michael V. Seidan, MD, PhD
To the Editor: Fiocchi and colleagues (1) recently presented evidence that sera from patients with inflammatory bowel disease killed intestinal epithelial cell-associated component (ECAC) coated erythrocytes in an antibody dependent cellular cytotoxicity assay (ADCC). This cytotoxicity may have been due to antibody recognition of a 137- and 160-kilodalton protein found in the P1 fraction of ECAC. An identical ADCC activity was also seen in a large fraction of asymptomatic family members. Specificity of anti-ECAC activity was demonstrated through almost complete lack of ADCC activity in sera from patients with other gastrointestinal and autoimmune diseases. The authors suggested that the discordance
Seidan MV. Environmental or Genetic Effects in Inflammatory Bowel Disease. Ann Intern Med. ;111:445–446. doi: 10.7326/0003-4819-111-5-445
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Published: Ann Intern Med. 1989;111(5):445-446.
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