Elio Cacciola, MD; Rosario Giustolisi, MD; Roberto Musso, MD; Angela Longo, BD; Emma Cacciola, MD
Chronic leg ulcers are a common distressing complication in patients with sickle cell-beta thalassemia and are difficult to heal. The pathogenic mechanism of this complication is not known although some factors have been implicated, such as severe anemia or zinc deficiency (1, 2). In this context, however, it is significant that persons with either beta-thalassemia or sickle-cell anemia are regarded as being at thrombotic risk (3, 4).
In sickle-cell disease, the recurrent vasocclusive episodes occurring in several areas of the body have been reported to be related to the sickling, which in turn can trigger the activation of blood coagulation
Cacciola E, Giustolisi R, Musso R, Longo A, Cacciola E. Antithrombin III Concentrate for Treatment of Chronic Leg Ulcers in Sickle Cell-Beta Thalassemia: A Pilot Study. Ann Intern Med. ;111:534–536. doi: 10.7326/0003-4819-111-6-534
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Published: Ann Intern Med. 1989;111(6):534-536.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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