Alicia Domingo, MD; Vicente Romagosa, MD; Manuel Callis, MD; Pilar Vivancos, MD; Nieves Guionnet, MD; Jesus Soler, MD
To the Editor: Mediastinal germ cell tumors are considered variants of testicular germ cell neoplasms, which occur infrequently in humans (1). The association of mediastinal germ cell tumors with different types of hematologic malignancies has been described in at least 20 patients (1-4). We report the case of a man who had acute megakaryoblastic leukemia (M7) with simultaneous occurrence of a primary mediastinal germ cell tumor.
A 31-year-old man presented with a 2-week history of a temperature of 39 °C and hemorrhagic syndrome (ecchymosis and purpura). The rest of the physical examination was normal including the examination of the testes.
Domingo A, Romagosa V, Callis M, Vivancos P, Guionnet N, Soler J. Mediastinal Germ Cell Tumor and Acute Megakaryoblastic Leukemia. Ann Intern Med. ;111:539. doi: 10.7326/0003-4819-111-6-539
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Published: Ann Intern Med. 1989;111(6):539.
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