Richard Peto, MA, MSc; Rory Collins, MBBS; Peter Sleight, MD, DM
To the Editor: The article by Lee and colleagues (1) and the accompanying editorial by Tate and Dehmer (2) on the smallness of the proportion of patients "eligible" for thrombolytic therapy makes it clear that in deciding who should be offered thrombolytics many U.S. physicians may simply adopt the restrictive eligibility criteria of those trials (3-5) that excluded older patients, treated only those presenting within a few hours of symptom onset, and required "definite" electrocardiographic (ECG) evidence of infarction. Such "restrictive-entry" trials cannot, however, provide direct evidence as to whether their restrictions were appropriate—that is, they obviously cannot assess directly
Peto R, Collins R, Sleight P. Wider Inclusion Criteria Needed for Thrombolytic Therapy. Ann Intern Med. ;111:540. doi: 10.7326/0003-4819-111-6-540_1
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Published: Ann Intern Med. 1989;111(6):540.
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