A. Sureda, MD; J. Pérez de Oteyza, MD; J. García Laraña, MD; J. Odriozola, MD, PhD
To the Editor: High-dose bulsulfan and cyclophosphamide are currently used as a conditioning regimen for bone marrow transplantation in hematologic malignancies (1, 2) and in nonmalignant diseases (3). Although myelosupression, interstitial pulmonary fibrosis, gastrointestinal symptoms, and an Addison-like wasting syndrome are well-recognized side effects of busulfan (4), we know of only one case of myoclonic epilepsy associated to high-dose busulfan that has been reported (5). We report a patient who presented with generalized convulsions while receiving high-dose busulfan.
An 18-year-old man with a Ph-positive acute lymphocytic leukemia in second remission was entered in an allogeneic bone marrow transplantation program with
Sureda A, de Oteyza JP, Laraña JG, Odriozola J. High-Dose Busulfan and Seizures. Ann Intern Med. ;111:543–544. doi: 10.7326/0003-4819-111-6-543_2
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Published: Ann Intern Med. 1989;111(6):543-544.
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