Edward L. Murphy, MD, MPH; J. Peter Figueroa, MBBS, DPH; William N. Gibbs, MD; Alfred Brathwaite, MB, ChB, DPH; Marjorie Holding-Cobham, MBBS, DPH; David Waters, PhD; Beverley Cranston, BSc; Barrie Hanchard, MBBS; William A. Blattner, MD
Study Objective: To study the seroprevalence of human T-lymphotropic virus type I (HTLV-I) in a sexually active population and to determine sexual behavior risk factors for infection.
Design: Cross-sectional seroprevalence study using enzyme-linked immunosorbent assay (ELISA) and Western blot. Risk-factor data were gathered by administered questionnaire and chart review.
Setting: Two urban, primary care clinics for persons with sexually transmitted diseases run by the Jamaican Ministry of Health.
Patients: Of the 2050 consecutive patients presenting with new episodes of sexually transmitted disease, 1977 patients were eligible for analysis.
Measurements and Results: Overall HTLV-I seroprevalence was 5.7%; prevalence increased with age from 1.6% (age, 14 to 19 years) to 5.1% (age, 30 years and older) in men and from 5.3% (age, 14 to 19 years) to 14.1% (age, 30 years and older) in women. Compared with a reference cohort of food service employees, age-adjusted HTLV-I seroprevalence was increased in female patients with sexually transmitted disease (odds ratio = 1.83; CI, 1.41 to 2.83) but not in male patients with sexually transmitted disease. Independent risk factors for HTLV-I infection in women included having had more than ten lifetime sexual partners (odds ratio = 3.52; CI, 1.28 to 9.69) and a current diagnosis of syphilis (odds ratio = 2.12; CI, 1.12 to 3.99). In men, a history of penile sores or ulcers (odds ratio = 2.13; CI, 1.05 to 4.33) and a current diagnosis of syphilis (odds ratio = 3.56; CI, 1.24 to 10.22) were independent risk factors for HTLV-I infection. Of 1977 patients, 5 (0.3%) had antibodies to human immunodeficiency virus type 1 (HIV-1), including 2 with HTLV-I and HIV-I coinfection.
Conclusions: We conclude that HTLV-I is transmitted from infected men to women during sexual intercourse. Our data are consistent with the lower efficiency of female-to-male sexual transmission of HTLV-I, but penile ulcers or concurrent syphilis may increase a man's risk of infection.
Edward L. Murphy, J. Peter Figueroa, William N. Gibbs, Alfred Brathwaite, Marjorie Holding-Cobham, David Waters, et al. Sexual Transmission of Human T-Lymphotropic Virus Type I (HTLV-I). Ann Intern Med. 1989;111:555–560. doi: 10.7326/0003-4819-111-7-555
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Published: Ann Intern Med. 1989;111(7):555-560.
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