J.C. Gallagher, MD; B.L. Riggs, MD
To the Editor: In a double-blind, randomized, placebo-controlled 2-year clinical trial reported in a recent issue, Ott and Chesnut (1) concluded that "calcitriol treatment is not effective in postmenopausal osteoporosis." We disagree. Whereas the authors are to be commended for a comprehensive and well-done clinical trial, we believe that their results are applicable only to the conditions of their study and should not be generalized.
Their study was part of a three-center trial that was run according to a common basic protocol. Both Aloia and colleagues (2) and Gallagher and colleagues (3), from the other participating centers, reported that calcitriol
Gallagher J, Riggs B. Calcitriol for Postmenopausal Osteoporosis. Ann Intern Med. ;111:621. doi: 10.7326/0003-4819-111-7-621_1
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Published: Ann Intern Med. 1989;111(7):621.
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