Catherine C. Hart, MD
To the Editor: Aerosolized pentamidine is now widely used for prophylaxis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Aerosolized pentamidine is believed to have fewer side effects than are associated with either intravenous or intramuscular administration. The apparent safety of aerosolized pentamidine is thought to be due to low systemic levels of the drug (serum level < 10 ng/mL after aerosolized administration  compared with 209 ng/mL and 612 ng/mL after intramuscular and intravenous administration, respectively . Pancreatitis has been reported with intravenous pentamidine therapy (3, 4) but to my knowledge has not been recognized
Hart CC. Aerosolized Pentamidine and Pancreatitis. Ann Intern Med. ;111:691. doi: 10.7326/0003-4819-111-8-691_1
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Published: Ann Intern Med. 1989;111(8):691.
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