Kenneth Radack, MD; Colleen Deck, PharmD; Gertrude Huster, MHS
Increased concentrations of plasma fibrinogen have been positively correlated with accelerated atherosclerosis in prospective epidemiologic studies (1-3) and have been shown to be a significant independent predictor for stroke (2-4) and coronary artery disease (3). In addition, raised fibrinogen levels are one of several components contributing to a "hypercoagulable state" associated with hypertriglyceridemia (5). Because of the relation between lipid metabolism, thrombosis, and atherogenesis (6), the responsiveness of fibrinogen levels to dietary interventions may have potential clinical significance. Marine n-3 fatty acid supplementation has been shown to have beneficial antiatherogenic actions related to atherosclerosis, thrombosis, and lipid metabolism (7). Although
Radack K, Deck C, Huster G. Dietary Supplementation with Low-Dose Fish Oils Lowers Fibrinogen Levels: A Randomized, Double-Blind Controlled Study. Ann Intern Med. ;111:757–758. doi: 10.7326/0003-4819-111-9-757
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Published: Ann Intern Med. 1989;111(9):757-758.
Cardiology, Coronary Risk Factors, Dyslipidemia, Hospital Medicine.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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