Esther Granot, MD; David Raveh, MD; Rami Eliakim, MD
To the Editor: Vitamin E deficiency resulting from prolonged fat malabsorption is associated with a progressive neuromyopathy and ophthalmoplegia. In abetalipoproteinemia, retinopathy and neurologic manifestations may be prevented by vitamin E supplementation (1). In infants with very low birthweight, vitamin E deficiency may present as hemolytic anemia and edema (2). Vitamin E deficiency has not been implicated as a cause of edema in any other age group.
We recently treated a 32-year-old woman who had had bilateral asymmetrical pitting edema of the lower limbs since 17 years of age. Blood protein levels, cardiac studies, Doppler venous recordings, and thyroid function
Granot E, Raveh D, Eliakim R. Vitamin E Deficiency and Peripheral Edema. Ann Intern Med. ;111:859. doi: 10.7326/0003-4819-111-10-859_1
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Published: Ann Intern Med. 1989;111(10):859.
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