Charles B. Payne Jr., MD; Helen E. Sloan, MD
To the Editor: The chronic fatigue syndrome has received considerable attention since its appearance approximately 4 years ago. Reports have focused on the immunologic evidence of Epstein-Barr virus infection in the pathogenesis of the syndrome. A working case definition was recently published (1). We have studied a 35-year-old woman who had the persistent symptoms of exertional dyspnea, malaise, and the inability to work because of a febrile "viral" illness that had presented about 6 months previously and was initially associated with muscle weakness and cough. Her symptoms met the working definition of the syndrome. On 27 February 1989, her quantitative
Payne CB, Sloan HE. Pulmonary Function and the Chronic Fatigue Syndrome. Ann Intern Med. 1989;111:860. doi: 10.7326/0003-4819-111-10-860_1
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Published: Ann Intern Med. 1989;111(10):860.
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