Disulfiram is an established drug that has been used in the clinical treatment of alcoholism for 40 years. It will produce an aversive reaction with ethanol in a person who takes a pharmacologically adequate dose, usually between 250 mg and 500 mg per day (1-9), although some patients may not have an aversive reaction at this level (10, 11). In some persons, it may have a relatively narrow therapeutic index with cardiac, hepatic, and neurologic toxicity occurring within this dosage range (12-25). The evidence suggests that disulfiram can be effective over the short term in reducing the frequency of alcohol
Disulfiram Treatment of Alcoholism. Ann Intern Med. ;111:943–945. doi: 10.7326/0003-4819-111-11-943
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Published: Ann Intern Med. 1989;111(11):943-945.
Tobacco, Alcohol, and Other Substance Abuse.
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