James W. Findling, MD; Brian P. Buggy, MD
To the Editor: LoPresti and colleagues (1) recently described unique alterations in thyroid hormone indices in patients with the acquired immunodeficiency syndrome (AIDS). They reported elevations of thyroid binding globulin which reflected the progression of the underlying human immunodeficiency virus (HIV) infection; however, they did not describe frank elevations of serum thyroxine (T4) in their patients, presumably due to other factors known to lower T4 in patients with chronic or acute nonthyroidal illnesses. We report two patients with AIDS and significant euthyroid hyperthyroxinemia resulting from increases in thyroid binding globulin.
Patient 1. A 60-year-old man with hemophilia A and transfusion-related
Findling JW, Buggy BP. Thyroid Hormones and the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. ;111:951. doi: 10.7326/0003-4819-111-11-951_1
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Published: Ann Intern Med. 1989;111(11):951.
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