Jean-Pierre Laaban, MD; Myrna Waked, MD; Muriel Laromiguiere, PharmD; Tu-Khanh Vuong, MD; Jacques Rochemaure, MD
The correction of acute respiratory acidosis by mechanical ventilation in patients with chronic obstructive pulmonary disease has been shown to induce hypophosphatemia (1-3). In patients with acute respiratory failure, hypophosphatemia may have harmful effects because it may decrease diaphragmatic contractility (4) and impair tissue oxygenation by causing a decrease in the erythrocyte 2,3-diphosphoglycerate concentration (5). However, the variations in serum phosphorus levels have not been studied in other settings of acute respiratory acidosis. We aimed to determine whether hypophosphatemia may develop during the treatment of acute severe asthma.
We did a prospective study of 18 consecutive patients
Jean-Pierre Laaban, Myrna Waked, Muriel Laromiguiere, Tu-Khanh Vuong, Jacques Rochemaure. Hypophosphatemia Complicating Management of Acute Severe Asthma. Ann Intern Med. 1990;112:68–69. doi: 10.7326/0003-4819-112-1-68
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Published: Ann Intern Med. 1990;112(1):68-69.
Asthma, Pulmonary/Critical Care.
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