Francis P. Arena, MD; Susan Sherlock, MD
To the Editor: Doxorubicin hydrochloride (Adriamycin, Adria Laboratories, Dublin, Ohio) and daunomycin anthracycline antibiotics are derived from Streptomyces peucetius var. caesius. There have been only a few reports (1, 2) of urticarial reactions to intravenous administration of Adriamycin or daunomycin and even fewer of more systemic allergic reactions to Adriamycin administration (3). We report two cases in which patients had a significant allergic reaction to Adriamycin or daunomycin. The patients had either previous exposure or a history of allergy to clindamycin.
A 5 8-year-old white woman diagnosed with stage III diffuse histiocytic lymphoma received gentamicin, clindamycin, and cefazolin after laparotomy.
Arena FP, Sherlock S. Doxorubicin Hypersensitivity and Clindamycin. Ann Intern Med. ;112:150. doi: 10.7326/0003-4819-112-2-150_1
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Published: Ann Intern Med. 1990;112(2):150.
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