William H. Daughaday, MD
In this issue, Ho and colleagues (1) summarize their considerable experience in treating acromegaly with the long-acting somatostatin analog, octreotide. This agent has a much longer biologic half-life than somatostatin and its effects persist from 4 to 8 hours. Ho and colleagues found that when octreotide was administered twice a day, little additional benefit was gained by increasing each dose from 100 to 500 μg. Serum growth hormone (GH) was lowered more successfully with three doses a day but little benefit was added by increasing the amount of each dose from 100 to 500 μg. Some patients are resistant to
Daughaday WH. Octreotide Is Effective in Acromegaly But Often Results in Cholelithiasis. Ann Intern Med. ;112:159–160. doi: 10.7326/0003-4819-112-3-159
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Published: Ann Intern Med. 1990;112(3):159-160.
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