Victor Vargas, MD; Luis Castells, MD; Juan I. Esteban, MD
To the Editor: Although evidence implicates the hepatitis B virus in the pathogenesis of hepatocellular carcinoma (1), other factors such as alcohol or chronic infection by non-A, non-B hepatitis agents have also been implicated, particularly in developed countries. Several documented cases of hepatocellular carcinoma following chronic non-A, non-B hepatitis have been reported in developed countries (2).
The isolation of the major bloodborne non-A, non-B hepatitis agent, hepatitis C virus (HCV), by cloning (3) has led to the development of assays for the detection of specific antibodies (4). In a previous report (5), we showed that HCV infection is present in
Vargas V, Castells L, Esteban JI. High Frequency of Antibodies to the Hepatitis C Virus among Patients with Hepatocellular Carcinoma. Ann Intern Med. ;112:232–233. doi: 10.7326/0003-4819-112-3-232_2
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Published: Ann Intern Med. 1990;112(3):232-233.
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