Robert W. Colman, MD
To the Editor: Lian and colleagues (1) reported 12 patients and reviewed the literature for the use of combination immunosuppressive therapy and factor VIII administration to treat FVIII antibodies. They credited Green (2) with originating the idea that patients will respond to steroids or cytotoxic agents or both after factor VIII concentration is infused. The rationale that Green (2) promulgated is that factor VIII stimulates the antibody-producing cells, allowing more effective killing of cells by cytotoxic agents. However, the authors neglected a study in which I participated (3), which appeared in 1970, 1 year before Green's article. We treated two
Colman RW. Immunosuppressive Therapy for Factor VIII Inhibitors. Ann Intern Med. ;112:233. doi: 10.7326/0003-4819-112-3-233_1
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Published: Ann Intern Med. 1990;112(3):233.
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