Denson G. Fujikawa, MD
To the Editor: As a neurologist who treats patients with status epilepticus, I disagree strongly with the suggestion by Blaser and colleagues (1) that their loading regimen for intravenous phenytoin, even when combined with intravenous diazepam, should be used to treat those with this condition. Status epilepticus can cause brain damage (2) and permanent memory impairment (3) in humans. Irreversible brain damage has been documented after a seizure period as short as 90 minutes in the baboon (4). In some instances seizures will continue even after phenytoin and diazepam have been given, and other anticonvulsants or even general anesthesia may
Fujikawa DG. Single-Dose Phenytoin Infusion. Ann Intern Med. ;112:235–236. doi: 10.7326/0003-4819-112-3-235_2
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Published: Ann Intern Med. 1990;112(3):235-236.
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