Alain H. Rook, MD; Brian V. Jegasothy, MD; Peter Heald, MD; George T. Nahass, MD; Chérie Ditre, MD; William K. Witmer, BS; Gerald S. Lazarus, MD; Richard L. Edelson, MD
The extracorporeal exposure of pathogenic peripheral blood leukocytes to the natural compound 8-methoxypsoralen (8-MOP) and ultraviolet A radiation has provided great benefit in certain advanced forms of cutaneous T-cell lymphoma (1). Extracorporeal photochemotherapy was given to four patients with persistent cases of the autoimmune blistering disease, pemphigus vulgaris, who had previously needed large doses of immunosuppressive drugs to control their disabling disease. Two representative cases are described in detail.
A 61-year-old man who had extensive blisters and erosions that had been resistant to many months of prednisone and azathioprine therapy had extracorporeal photochemotherapy initiated with treatments
Rook AH, Jegasothy BV, Heald P, Nahass GT, Ditre C, Witmer WK, et al. Extracorporeal Photochemotherapy for Drug-Resistant Pemphigus Vulgaris. Ann Intern Med. ;112:303–305. doi: 10.7326/0003-4819-112-4-303
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Published: Ann Intern Med. 1990;112(4):303-305.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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