Jacobo Wortsman, MD; William B. Malarkey, MD
To the Editor: We read with interest the excellent review on thyrotropin-secreting pituitary adenomas by Gesundheit and colleagues (1). Elevated serum prolactin levels were found in seven of their nine patients. Although the presence of hyperprolactinemia in the setting of hyperthyroidism is unusual, the abnormality is not confined solely to thyrotropin-secreting tumors. In several patients, hyperthyroidism has also been associated with macroprolactinemia, a nontumoral entity characterized by high circulating levels of prolactin molecules of very large molecular weight (macroprolactin) (2). Abnormally elevated concentrations of macroprolactin have been found in both men and women (3) and do not usually interfere with
Wortsman J, Malarkey WB. Hyperthyroidism, Hyperprolactinemia, and Macroprolactinemia. Ann Intern Med. ;112:309. doi: 10.7326/0003-4819-112-4-309_1
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Published: Ann Intern Med. 1990;112(4):309.
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