Peter Knoflach, MD; Christian Müller, MD; Martha M. Eibl, MD
To the Editor: Despite the proven effectiveness of corticosteroids in treating active Crohn disease, the search for therapeutic alternatives has continued; one of the reasons for the continuing search is the overlap of the extra-intestinal manifestations of Crohn disease with the side effects of long-term corticosteroid treatment (for example, osteoporosis). Postulating an effect on endotoxin clearance or on immunoregulation, some investigators used intravenous immunoglobulins for treating Crohn disease in two uncontrolled pilot studies (1, 2). Although some patients seemed to respond well to treatment with intravenous immunoglobulins, the numbers of patients were small, follow-up periods were short, and—most important—immunoglobulin therapy
Knoflach P, Müller C, Eibl MM. Crohn Disease and Intravenous Immunoglobulin G. Ann Intern Med. ;112:385–386. doi: 10.7326/0003-4819-112-5-385
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Published: Ann Intern Med. 1990;112(5):385-386.
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