Jeffrey A. Jackson, MD; Mitchell Smigiel, MD
To the Editor: Hyperthyroidism is rarely caused by thyrotropin (TSH)-secreting pituitary tumors (1-3). By the time of diagnosis, these tumors are often large and are incurable by surgery alone (3). We recently reported the case of a patient who presented with moderately severe hyperthyroidism and an inappropriate secretion of TSH as measured by a highly sensitive immunoradiometric assay (2, 4). An 8-mm thyrotroph cell adenoma was removed by selective transsphenoidal microadenomectomy. We report the results of the patient's postoperative thyroid hormone testing.
Six weeks after surgery, the patient developed sluggishness and cold intolerance. Triiodothyronine (T3), 25 µg twice daily, was
Jackson JA, Smigiel M. Hypothyroidism and Thyrotropin-Secreting Pituitary Microadenomectomy. Ann Intern Med. ;112:388. doi: 10.7326/0003-4819-112-5-388_1
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Published: Ann Intern Med. 1990;112(5):388.
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