Uri Khazan, MD; Mary Toth, MD; Anand Mutgi, MD
To the Editor: No reports to date have described prolonged bleeding time and spontaneous bruising with the use of diclofenac sodium. A literature search (Index Medicus and Excerpta Medica) revealed a single study that described reversible inhibition of platelet aggregation without prolongation of bleeding time with the use of diclofenac sodium (1). Moreover, the manufacturer (Geigy) reports no effect on bleeding time with its use (2). We report a case of spontaneous bruising and prolongation of bleeding time temporally associated with the use of diclofenac sodium.
An otherwise healthy 45-year-old woman complained of spontaneous bruising for 1 week. She denied
Khazan U, Toth M, Mutgi A. Diclofenac Sodium and Bruising. Ann Intern Med. ;112:472–473. doi: 10.7326/0003-4819-76-3-112-6-472_2
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Published: Ann Intern Med. 1990;112(6):472-473.
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