James E. Everhart, MD; Adrian M. Di Bisceglie, MD; Linda M. Murray, RN; Harvey J. Alter, MD; Jacqueline J. Melpolder, MT; George Kuo, PhD; Jay H. Hoofnagle, MD
Transmission of non-A, non-B hepatitis through parenteral exposures, including drug abuse, blood transfusion, and occupational injury with a needle contaminated with blood is well documented (1). Other means of non-A, non-B hepatitis transmission must occur, since at least 50% of patients do not have a history of parenteral exposure (2, 3). Personal contact as a route of infection has been reported (4), but not shown conclusively, and the actual risk for such transmission is unknown.
Recently, the genome of the hepatitis C virus (HCV), the major agent that causes non-A, non-B hepatitis, has been isolated (5). Antibody to hepatitis C
Everhart JE, Di Bisceglie AM, Murray LM, Alter HJ, Melpolder JJ, Kuo G, et al. Risk for Non-A, Non-B (Type C) Hepatitis through Sexual or Household Contact with Chronic Carriers. Ann Intern Med. ;112:544–545. doi: 10.7326/0003-4819-112-7-544
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Published: Ann Intern Med. 1990;112(7):544-545.
Gastroenterology/Hepatology, Liver Disease.
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