P.H. Chandrasekar, MD; R. Cushing, MD
To the Editor: Adverse renal effects of captopril, as listed in the Physicians' Desk Reference (PDR-1989), do not include microscopic hematuria and hemoglobin casts. Recently, one of the authors (P.H.C.) developed these urinary abnormalities while taking the drug.
In May 1989, P.H.C. (41-year-old, previously healthy man), on a routine physical examination, was diagnosed with essential hypertension and placed on captopril therapy. With a 25-mg dose twice daily, P.H.C.'s blood pressure was easily controlled. Since the initiation of captopril therapy, P.H.C. noted increased urinary frequency, gradual weight loss, and easy fatiguability. Complete blood count and urinalysis were within normal limits. The
Chandrasekar P, Cushing R. Captopril and Glomerulitis. Ann Intern Med. ;112:550. doi: 10.7326/0003-4819-112-7-550_1
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Published: Ann Intern Med. 1990;112(7):550.
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