Cindy A. Leissinger, MD
During the past 15 months, six habitual cocaine users have been evaluated for severe, destructive thrombocytopenia with platelet counts of less than 20 x 109/L. None of our patients had antibodies to type 1-human immunodeficiency virus (HIV) and five of five tested were negative for antibodies to human T-cell lymphotrophic virus type I (HTLV-I), a reportedly common finding in intravenous drug users in the New Orleans area (1). Five patients used cocaine intravenously, whereas the sixth patient used cocaine only by inhalation. A direct, causal relation between cocaine use and thrombocytopenia that is unrelated to retroviral infection is suggested, with
Leissinger CA. Severe Thrombocytopenia Associated with Cocaine Use. Ann Intern Med. ;112:708–710. doi: 10.7326/0003-4819-112-9-708
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Published: Ann Intern Med. 1990;112(9):708-710.
Hematology/Oncology, Platelet Disorders, Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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