Gregory J. del Zoppo, MD; Anthony Furlan, MD; Werner Hacke, MD
To the Editor: We read with admiration the recent editorial of Barsan and colleagues (1) regarding their experience with "trauma-style" approaches to early treatment for acute ischemic stroke. Clearly, entry of patients within 90 minutes of symptom onset requires an efficient and labor-intensive accrual system, currently available in few communities. Although we agree that "early treatment should be a priority in future treatment trials of acute ischemic stroke," several significant and practical limitations revealed by recent acute stroke trials should not be overlooked.
Clinical trials of acute stroke should be based on rational, clinically testable hypotheses and therapeutic approaches. For
del Zoppo GJ, Furlan A, Hacke W. Treatment of Acute Stroke. Ann Intern Med. ;112:713. doi: 10.7326/0003-4819-112-9-713_1
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Published: Ann Intern Med. 1990;112(9):713.
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