Timothy B. Seaton, MD; Nancy Coombe; Abraham Mittelman, MD
To the Editor: The role of tumor necrosis factor (cachectin) in the pathogenesis of cachexia from cancer and other chronic diseases remains to be fully explored. Tumor necrosis factor (TNF) inhibits lipoprotein lipase in vitro and causes depletion of fat stores and muscle wasting in animal models (1). We suggest that TNF may also be responsible for alterations in resting metabolic rate.
We measured the resting metabolic rate and respiratory quotient in the fasting state by indirect calorimetry in two patients receiving a 24-hour infusion of human recombinant TNF-alpha (200 µg/m2 body surface area daily) as part of a phase
Seaton TB, Coombe N, Mittelman A. Tumor Necrosis Factor and Hypermetabolism. Ann Intern Med. ;112:715–716. doi: 10.7326/0003-4819-112-9-715_2
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Published: Ann Intern Med. 1990;112(9):715-716.
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