John Ruedy, MD; Martin Schechter, MD; Julio S. G. Montaner, MD
Since it was originally described in 1981, the acquired immunodeficiency syndrome (AIDS) has been a complex therapeutic challenge. In 1983, the discovery of human immunodeficiency virus type 1 (HIV) as the causative agent of AIDS opened the door for the rational development of specific therapeutic agents. To date, only one such agent, zidovudine (also known as azidothymidine, or AZT) has been definitively shown to alter the usually rapidly fatal course of AIDS (1, 2). Results of a number of recently concluded trials, some of them still unpublished, in patients at earlier stages of HIV infection necessitate a reassessment of our
John Ruedy, Martin Schechter, Julio S. G. Montaner. Zidovudine for Early Human Immunodeficiency Virus (HIV) Infection: Who, When, and How?. Ann Intern Med. 1990;112:721–723. doi: 10.7326/0003-4819-112-10-721
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Published: Ann Intern Med. 1990;112(10):721-723.
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