Andrew Freese; Stephen F. Finn; Matthew J. During
To the Editor: Since the initial description of the eosinophilia-myalgia syndrome and recognition of its link to tryptophan ingestion, we have received several inquiries regarding our previous letter on the potential neurotoxicity of tryptophan (1). Our concern focused on the metabolic relation between tryptophan and the known neurotoxin, quinolinic acid, which acts as an agonist of the N-methyl-D-aspartate excitatory amino acid receptor. Since then, we have shown a dramatic responsiveness of brain extracellular fluid levels of quinolinic acid to tryptophan loading in rats (2). A single intraperitoneal dose of tryptophan (100 mg/kg body weight) elevated striatal brain extracellular fluid quinolinic
Freese A, Finn SF, During MJ. The Eosinophilia-Myalgia Syndrome. Ann Intern Med. ;112:795–796. doi: 10.7326/0003-4819-112-10-795
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Published: Ann Intern Med. 1990;112(10):795-796.
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