James F. Burris, MD
To the Editor: It is very unfortunate that the TAIM (Trial of Antihypertensive Interventions and Management) study lasted only 6 months (1). It has been well known for some time that thiazide diuretics initially increase both total and low-density lipoprotein (LDL) cholesterol. The lipid changes probably peak at 6 to 9 months, and cholesterol declines to or below baseline thereafter (2). Such a relatively transient increase in cholesterol would not be expected to have any long-term effect on coronary risk. The TAIM study thus assessed chlorthalidone at the worst possible time for evaluating the long-term effect of thiazides on cardiovascular
Burris JF. Mild Hypertension and Cardiovascular Risks. Ann Intern Med. 1990;112:879. doi: 10.7326/0003-4819-112-11-879_1
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Published: Ann Intern Med. 1990;112(11):879.
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