Thomas Ochsenkühn; Matthias M. Weber, MD; Wolfgang H. Caselmann, MD
To the Editor: We read with interest the UCLA conference on molecular mimicry in HLA-B27-related arthritis (1). The authors propose that a cross-reactivity between HLA-B27 and antigenic bacterial components is the mechanism underlying the pathogenesis of synovial injury in reactive arthritis occurring after infection. Because of this mimicking effect, the immune response of the organism is directed against HLA-B27-positive cells. Similarly, shared antigenic determinants of a cartilage proteoglycan and Mycobacterium bovis, strain BCG (Calmette-Guerin bacillus), are responsible for adjuvant arthritis in rats.
We report a case of BCG-induced severe arthritis in a man who received BCG immunotherapy for carcinoma of
Ochsenkühn T, Weber MM, Caselmann WH. Arthritis after Mycobacterium bovis Immunotherapy for Bladder Cancer. Ann Intern Med. 1990;112:882. doi: 10.7326/0003-4819-112-11-882_2
Download citation file:
Published: Ann Intern Med. 1990;112(11):882.
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use