Eitan Shiloni, MD; Eitan Gross, MD; Mervyn Shapiro, MD
To the Editor: Snydman and colleagues (1) recently addressed the frequency of nosocomial infection in interleukin-2 (IL-2) therapy for advanced malignancies. The issue is specifically one of central-venous-catheter-related sepsis. Patients in this study had subclavian double-lumen catheters placed for intravenous access. Only 2 of the 20 episodes of bacteremia reported were clearly not catheter-related; the other 18 were regarded as definitely (n = 12) or probably (n = 2) catheter-related, or were suspected of being catheter-related (n = 4). Another recent study (2) was done at the National Cancer Institute to determine the efficacy of prophylactic antimicrobial drugs in preventing
Shiloni E, Gross E, Shapiro M. Interleukin-2 Therapy, Central Venous Catheters, and Nosocomial Sepsis. Ann Intern Med. ;112:882–883. doi: 10.7326/0003-4819-112-11-882_3
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Published: Ann Intern Med. 1990;112(11):882-883.
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