Nelson J. Chao, MD; Karl G. Blume, MD
Allogeneic bone marrow transplantation is entering its third decade as a curative therapeutic modality for treating certain malignant and nonmalignant diseases. Some controversies still surround its use. One controversy pertains to the proper timing of marrow transplantation for the acute leukemias, specifically for acute lymphoblastic leukemia in the adult patient. The appropriate time to proceed to marrow transplantation depends on the stage of the disease.
The use of modern combination chemotherapy in adults who have a relapse after their first remission is associated with a dismal prognosis; there are only a few anecdotal case reports of long-term, disease-free survival. In
Chao NJ, Blume KG. Bone Marrow Transplantation: What Is the Question?. Ann Intern Med. ;113:340–341. doi: 10.7326/0003-4819-113-5-340
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Published: Ann Intern Med. 1990;113(5):340-341.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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