U. Aebi, MD; W. H. Reinhart, MD
To the Editors: A 63-year-old woman died from acute liver failure while being treated with beclobrate, a lipid lowering agent. She had moderate hyperlipidemia, which had been treated by her physician with bezafibrate for 8 years. The drug was later replaced by beclobrate, 100 mg/d, because of persistently high cholesterol levels (7.8 mmol/L). After 4 months she developed vomiting and jaundice. She was only taking beclobrate during that time, and the drug was withdrawn. Jaundice rapidly progressed, and she was hospitalized with acute liver failure. No other abnormalities were found. She had no history of recent viral or bacterial infection,
Aebi U, Reinhart WH. Beclobrate and Liver Disease. Ann Intern Med. 1990;113:483. doi: 10.7326/0003-4819-113-6-483_2
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Published: Ann Intern Med. 1990;113(6):483.
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