Gregory L. Miller, MD
To the Editors: Graft arteriosclerosis following cardiac transplantation is a significant complication and is felt to have an immunologic cause. I describe a case of acute myocardial infarction in a transplant patient that was thought to be caused by underlying coronary atherosclerosis of the donor heart.
A 39-year-old woman, 3 months after an orthotopic heart transplant for severe ischemic cardiomyopathy, complained of fever for 1 week and other symptoms similar to two previous episodes of acute rejection. Both the admission chest roentgenogram, which showed an increased cardiac silhouette, and electrocardiogram, with decreased voltages, supported acute graft rejection. She was initially
Miller GL. Atherosclerosis in a Donor Heart. Ann Intern Med. ;113:484. doi: 10.7326/0003-4819-113-6-484_1
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Published: Ann Intern Med. 1990;113(6):484.
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