Peter Kalhs, MD; Peter Kier, MD; Klaus Lechner, MD
To the Editors: We have shown previously that functional asplenia is a late complication of allogeneic bone marrow transplantation, occurring only in patients with extensive chronic graft-versus-host disease, and that the appearance of Howell-Jolly bodies in peripheral blood smears indicates functional asplenia (1). Because our previous study was retrospective, the exact onset of functional asplenia could not be determined. We therefore conducted a prospective study to
determine the exact onset of functional asplenia and to confirm our previous findings.
Twenty-six bone marrow transplant recipients (12 women, 14 men) with a median age of 33 years (range, 20 to 47 years)
Kalhs P, Kier P, Lechner K. Functional Asplenia after Bone Marrow Transplantation. Ann Intern Med. ;113:805–806. doi: 10.7326/0003-4819-113-10-805
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Published: Ann Intern Med. 1990;113(10):805-806.
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