Anupam Agarwal, MD; V. Sakhuja, MD; K.S. Chugh, MD
To the Editors: Fluconazole, a new, effective, administered orally triazole antifungal agent (1), has been reported to be relatively free of serious side effects. Nausea, abdominal pain, asymptomatic elevation of liver enzymes, skin rash, and interaction with other drugs (for example, cyclosporin) have been documented (2, 3). In a recent study, Larsen and colleagues (4) observed thrombocytopenia (platelet count < 150 000/mm3) in both of their treatment groups (patients received either fluconazole or amphotericin B plus flucytosine) but did not associate it with study drug therapy. We report the case of a patient with disseminated cryptococcosis who was receiving fluconazole
Agarwal A, Sakhuja V, Chugh K. Fluconazole-Induced Thrombocytopenia. Ann Intern Med. ;113:899. doi: 10.7326/0003-4819-113-11-899_1
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Published: Ann Intern Med. 1990;113(11):899.
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