Kwame Osei, MD
Noninsulin-dependent (type II) diabetes mellitus is characterized by beta-cell dysfunction, insulin resistance, and hepatic glucose overproduction (1). That its primary etiology remains unknown is ironic, because type II diabetes has strong genetic and familial components. Indeed, in monozygotic twins, the concordance rate for this disease approaches 100% compared with 50% for type I diabetes (2). Further, the cumulative prevalence rate for the disease in the offspring of two diabetic parents ranges between 40% and 60%.
The earliest pathologic lesions seen in type II diabetes have been extensively sought over the past three decades. Most previous studies in humans were conducted
Osei K. Predicting Type II Diabetes in Persons at Risk. Ann Intern Med. ;113:905–907. doi: 10.7326/0003-4819-113-12-905
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Published: Ann Intern Med. 1990;113(12):905-907.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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