Jason Shen, MD; Antonella Quattromani, MD
To the Editors: We read with great interest the recent article by Lange and colleagues (1) but disagree with the conclusions. We wish to point out the existence of several large-scale, controlled clinical trials documenting the efficacy of intravenous beta blockade in reducing estimated infarct size, and both early and late mortality in acute myocardial infarction (2-4). Metoprolol and atenolol are the only beta-blocking agents approved for intravenous use in acute myocardial infarction in the United States. Both are considered beta-1-adrenergic or cardioselective blockers, as opposed to the group of nonselective beta-adrenergic blockers to which propranolol belongs. Lange and colleagues
Shen J, Quattromani A. Beta-Blockers for Cocaine-Induced Coronary Vasoconstriction. Ann Intern Med. ;113:993. doi: 10.7326/0003-4819-113-12-993_1
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Published: Ann Intern Med. 1990;113(12):993.
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