Ronald H. Lewis, MD
To the Editors: In the brief report on the effects of diltiazem and lisinopril on the proteinuria associated with diabetes mellitus, Bakris (1) incorrectly implied that it was the first report of a calcium-channel antagonist affecting urinary protein excretion in humans. However, nicardipine has been shown to reduce the albumin excretion rate in hypertensive patients with type II diabetes mellitus. Baba and colleagues (2) compared the renal effects of an angiotensin converting enzyme inhibitor with those of enalapril and nicardipine in seven hypertensive patients with type II diabetes and microalbuminuria, using a randomized, crossover triaL Patients were treated for 4
Lewis RH. Calcium-Channel Antagonists Reduce Renal Protein Excretion. Ann Intern Med. ;114:167–168. doi: 10.7326/0003-4819-114-2-167
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Published: Ann Intern Med. 1991;114(2):167-168.
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