George F. Gjerset, MD; James W. Mosley, MD
To the Editors: Mannucci and colleagues (1) reported the results of a hepatitis virus safety evaluation of 32 lots of factor VIII concentrate that were heat pasteurized in the liquid state. They tested serially collected serum samples obtained from 29 previously untreated hemophiliacs for antibody to hepatitis C virus (anti-HCV) and found no seroconversions. Similarly, they found no hepatitis B virus (HBV) infections among 15 HBV-seronegative subjects. Two aspects of their article warrant comment.
The safety of plasma products, including intravenous immunoglobulin preparations (2), should not be assumed by the physician who encounters a case in which there was exposure
Gjerset GF, Mosley JW. Safety of Factor VIII. Ann Intern Med. ;114:171. doi: 10.7326/0003-4819-114-2-171_1
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Published: Ann Intern Med. 1991;114(2):171.
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