Velimir A. Luketic, MD; Mitchell L. Shiffman, MD; Janice B. McCall, MD; Marc P. Posner, MD; A. Scott Mills; Robert L. Carithers Jr., MD
Orthotopic liver transplantation is an effective treatment for end-stage liver disease caused by chronic hepatitis B infection. Unfortunately, the new liver becomes reinfected with the virus in nearly all recipients (1). Many patients go on to develop chronic hepatitis B and cirrhosis (2). Because long-standing chronic hepatitis B infection is a risk factor for hepatocellular carcinoma (3, 4),these patients may also be at an increased risk for developing this tumor. We report the first documented case of primary hepatocellular carcinoma developing in the hepatic allograft of a patient with recurrent chronic hepatitis B. In this immunosuppressed patient, tumor developed after
Luketic VA, Shiffman ML, McCall JB, Posner MP, Mills AS, Carithers RL. Primary Hepatocellular Carcinoma after Orthotopic Liver Transplantation for Chronic Hepatitis B Infection. Ann Intern Med. ;114:212–213. doi: 10.7326/0003-4819-114-3-212
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Published: Ann Intern Med. 1991;114(3):212-213.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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