Stuart Jon Spechler, MD
In the 1950s, the British surgeon Norman Barrett called attention to a peculiar condition in which the distal esophagus is lined by columnar mucosa rather than by squamous epithelium (1). Barrett originally deemed this a congenital disorder, but authorities now consider the columnar cell-lined (Barrett) esophagus an acquired condition (2). Barrett esophagus has been thought to develop as a result of severe gastroesophageal reflux disease in most cases. In this issue of Annals, Sartori and colleagues (3) present compelling evidence that Barrett epithelium can also be acquired as a sequela of chemotherapy. This observation has important implications regarding the pathogenesis
Spechler SJ. Barrett Esophagus: A Sequela of Chemotherapy. Ann Intern Med. 1991;114:243–244. doi: 10.7326/0003-4819-114-3-243
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Published: Ann Intern Med. 1991;114(3):243-244.
Esophageal Disorders, Gastroenterology/Hepatology.
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